On 2005, Omotola Ekeinde was appointed an Ambassador of the United Nations World Food Programme, serving on missions in Liberia and Sierra Leone. She also backs groups that empower young women and youth in society, such Charles Odii’s SME100 Africa. She has been involved in the Walk the World initiative and joined President Ellen Johnson Sirleaf in Liberia for the Walk the World campaign. Her NGO project, the Omotola Youth Empowerment Program (OYEP), is the focal point of her human rights advocacy activity. The Empowerment Walk and Convention brought hundreds of young people together as a result of this endeavor.
In 2010, she contributed to Save the Children UK’s “Rewrite The Future” campaign. In 2011, she joined Amnesty International as a campaigner. She has since taken part in campaigns in Sierra Leone (Maternal Mortality) and Nigeria’s Niger Delta in 2012, where she filmed a video urging Shell plc and the government to “own up, clean up, pay up, and take responsibility for the oil spills in the Niger Delta.” Together with Tanzanian actress Wema Sepetu, she visited Tanzania Mitindo House, an orphanage home in Tanzania that specializes in HIV-infected children, in June 2020.
Since smoking had a detrimental effect on young children who looked up to them, Ekeinde and actors Daniel Effiong, Meg Otanwa, Michelle Dede, Osas Ighodaro, and Dakore Egbuson-Akande promised to quit smoking in their film roles in support of the #SmokeFreeNollywood campaign and 2021 World No Tobacco Day. Gatefield, a sub-Saharan public strategy consultancy, and Tobacco-Free Kids, a US non-profit, supported the campaign.
